Membrane Transition Temperature Determines Cisplatin Response

Membrane Transition Temperature Determines Cisplatin Response

Cisplatin is a classical chemotherapeutic agent used in treating several forms of cancer including head and neck. However, cells develop resistance to the drug in some patients through a range of mechanisms, some of which are poorly understood. Using isolated plasma membrane vesicles as a model system, we present evidence suggesting that cisplatin induced resistance may be due to certain change...

What Determines the Martensitic Transition Temperature in Alloys ?

Discontinuous Shear Modulus Determines the Glass Transition Temperature

A solid—amorphous or crystalline—is defined by a finite shear modulus while a fluid lacks such. We thus experimentally investigate the elastic properties of a colloidal glass former near the glass transition: Spectroscopy of vibrational excitations yields the dispersion relations of longitudinal and transverse phonons in the glassy state. From the long-wavelength limit of the dispersion relatio...

Effect of Asymmetric Functionalized Graphene Oxide (Janus GO) on Young′s Modulus and Glass Transition Temperature of PSf Ultrafiltration Membrane

   In this study, effect of asymmetric functionalized graphene oxide (Janus GO) on Young′s modulus and glass transition temperature of Polysulfone (PSf) ultrafiltration membranes was investigated. The membranes were prepared via phase inversion method and GO nanosheets were dispersed in casting solution by sonication. Results showed that the Normalized Young’s modulus (on the basis of neat ...

Effect of cisplatin treatment on the response to serotonin

  Although cisplatin is one of the most effective cancer drugs which is widely used in the treatment of various neoplasms, its side effects, especially vomiting may limit its use. It has been demonstrated that cytotoxic drugs lead to a sudden release of serotonin (5-HT). The following study was performed to determine the possible interactions of cisplatin with 5-HT receptors. In this study, the...